Paroxetine for Premature Ejaculation

Premature ejaculation, often referred to as PE, is when a man ejaculates always or nearly always within about 1 to 3 minutes of sexual activity. There are two types of PE: lifelong premature ejaculation and acquired premature ejaculation. Both can be treated through lifestyle and behavioural techniques as well as pharmacological methods.

One of the medications prescribed for PE symptoms is Paroxetine. Because Paroxetine is only available via prescription in Australia, it’s important to understand how it works in order to effectively and safely use it to treat PE.

What is Paroxetine?

Paroxetine is a medication that belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). It is a long-acting SSRI that is commonly prescribed for mood disorders like depression. However, it has been clinically proven that at lower doses than for mood disorders, Paroxetine is an effective premature ejaculation treatment. Paroxetine is an oral tablet that comes in 20mg tablets and is taken daily, regardless of whether you engage in sexual activity. Paroxetine is prescribed in dosages from 10mg up to 40mg for the management of PE.

How does Paroxetine work for premature ejaculation?

Paroxetine is a SSRI that is prescribed off-label to help treat PE symptoms. The way SSRIs work in general is by increasing serotonin levels in the brain. Serotonin impacts things like mood, emotion and sleep. By inhibiting the reuptake of serotonin, Paroxetine can help control and delay ejaculation.

When taken daily, Paroxetine can help treat PE in men of all ages.

Side effects of Paroxetine

Like all medications, there are potential side effects when taking Paroxetine. The most common mild side effects include:
- Nausea
- Headaches
- Dizziness
- Drowsiness

More serious side effects can occur. If you experience any of the following, call 000 for assistance.
- Fainting
- Seizures
- Blurred vision

Paroxetine compared to other premature ejaculation treatments

There are two types of SSRIs that can be used to treat PE: long-acting and short-acting. The only short-acting SSRI that is prescribed specifically for PE is Priligy. Priligy can be taken on-demand 1 to 3 hours before sex. 

Long-acting SSRIs include Fluoxetine (Prozac) and Paroxetine. These premature ejaculation tablets are prescribed at a lower dose than they would be as antidepressants or for treating other mood disorders. However, they are still highly effective in delaying and controlling ejaculation. Both are generally well tolerated and have been clinically proven to improve premature ejculation symptoms, which is why they are prescribed off-label for PE patients.

Some studies
have found that Paroxetine is more effective than Fluoxetine for treating PE, though it’s important to note that everyone is different and may have different reactions and responses to different medications.

Is Paroxetine safe?

Yes, Paroxetine is safe to use to treat premature ejaculation. However, it may not be suitable for men with a history of depression or other mental health disorders, low blood pressure or other heart problems, liver problems or kidney problems. Paroxetine should not be taken together with any medications to manage your mood such as antidepressants. It is important to disclose as much accurate medical information as possible to your doctor to assist them in providing the most appropriate treatment options for you.

Depending on your medical history, symptoms and needs, your doctor will prescribe an appropriate premature ejaculation treatment. Like all medications, there are potential side effects to be aware of. Always use your prescription medication exactly as prescribed and contact your doctor if you’re experiencing any issues.

Now you can get genuine, clinically proven PE medication online through Rosemary. Online assessments are 100% confidential and take about 5 minutes to complete. Start your visit with an online doctor for premature ejaculation treatment today.


BMC Urology (January 2019) - Paroxetine in the treatment of premature ejaculation: a systematic review and meta-analysis
Asian Journal of Andrology (May 2014) - Comparison of paroxetine and dapoxetine, a novel selective serotonin reuptake inhibitor in the treatment of premature ejaculation
International Brazilian Journal of Urology (December 2019) - Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? A randomized clinical trial
Australian Family Physician (October 2015) - Premature ejaculation: A clinical review for the general physician

ARTG Registered Medications:

Product PAROXETINE (AS HYDROCHLORIDE) tablet 20 mg (AF:2) tablet - film coated bulk is registered in the ARTG, AUST R, Product PAROXETINE SANDOZ paroxetine (as hydrochloride) 20mg tablet blister pack is registered in the ARTG, AUST R

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