Spedra (Avanafil) for ED Treatment

Erectile dysfunction is a common condition yet can be uncomfortable to talk about. However, there are ED medications available in Australia that are TGA-approved and safe to use. One of these ED medications is Spedra. The active ingredient in Spedra is Avanafil, a PDE5 inhibitor that works to treat ED. Because Spedra is only available by prescription in Australia, it’s important to understand how it works in order to use it safely and effectively.

What is Spedra?

Spedra is the brand name for a type of drug called Avanafil. Avanafil is the active ingredient in Spedra that works to treat erectile dysfunction. Spedra belongs to a class of drugs called phosphodiesterase type 5 (PDE5) inhibitors that are clinically proven to help treat ED in adult men of all ages. Spedra is an oral tablet that comes in doses ranging from 50 mg to 200 mg. Your doctor will prescribe an appropriate dosage based on your medical history, symptoms and needs.

How does Spedra work?

In order to understand how Spedra works, it’s helpful to understand how erections work. When a man is sexually aroused, his brain sends messages to his penis and releases chemicals. One of these chemicals is cyclic GMP which relaxes and widens the penile blood vessels as well as the muscles in the corpus cavernosa, or the erectile tissue. Through this process, blood flows into the penis and leads to a hard erection. 

When erections go away, it’s because an enzyme called PDE5 breaks down the cyclic GMP. That’s why PDE5 inhibitors are effective for erectile dysfunction; they prevent the PDE5 enzymes from breaking down cyclic GMP and causing erection loss. 

It’s important to note that Spedra, like other ED medications, only works if a man is sexually aroused. It does not help increase libido or sex drive and does not cure ED.

How long does Spedra take to work?

Of all the ARTG-registered erectile dysfunction medications, Spedra is the quickest to take effect with some men reporting results within 20 minutes after taking the pill. Doctors recommend taking Spedra about 30 minutes before engaging in sexual activity. You can take Spedra with or without food, though some men report faster results if taken on an empty stomach. 

Spedra remains in your system for about 6 hours. This does not mean that you will have an erection for 6 hours but rather you will continue to be able to achieve an erection firm enough for sex during the timeframe that the ingredients are still active in your bloodstream. 

Side effects of Spedra

Like all medications, Spedra comes with some potential side effects that are typically mild and brief. The most common side effects include:
- Headache
- Flushing
- Nasal congestion
In most cases, these side effects can disappear within a few hours.

Serious side effects are not common, but can occur. Call 000 if you feel severe side effects that include:
Sudden decrease or loss of vision
- Sudden decrease or loss of hearing
- Shortness of breath
- Chest pain or discomfort
- Irregular heartbeat
- Dizziness
- Allergic reaction
- Priapism (long-lasting and sometimes painful erection)

Spedra compared to other ED treatments

Other commonly prescribed ED medications include Viagra (Sildenafil), Cialis (Tadalafil) and Levitra (Vardenafil). All of these drugs are PDE5 inhibitors and work in a similar way to help with erectile dysfunction, though have slight differences that may make one more effective for you than another. 
Viagra (Sildenafil) and Levitra (Vardenafil) are similar in that they both reach peak effectiveness in an hour and stay in your bloodstream for about 4 to 5 hours. Both of these drugs can be less effective if taken after eating a heavy, fatty meal. It’s recommended to wait 2 to 3 hours after heavy meals before taking Levitra or Viagra for best results.

Cialis (Tadalafil) takes a bit longer to take effect and is recommended to take about 2 hours prior to sex. It also stays in your bloodstream longer - up to 36 hours. This means that you may be able to continue seeing the positive benefits of Cialis and Tadalafil for up to a day and half after you’ve taken the pill. 

Spedra is the quickest to take effect. Some men report results within 20 minutes of taking the drug, and it’s possible to see even faster results if taken on an empty stomach. Spedra remains in your system for about 6 hours. 

Is Spedra safe? 

Yes, Spedra is safe to use to treat erectile dysfunction. However, it may not be suitable for men with a history of high or low blood pressure, heart disease, stroke, liver disease, kidney disease, or vision loss, or men who are currently taking nitrites. It is important to disclose as much accurate medical information as possible to your doctor to assist them in providing the most appropriate treatment options for you.

Depending on your medical history, symptoms and needs, your doctor will prescribe an appropriate erectile dysfunction treatment. Like all medications, there are potential side effects to be aware of. Always use your prescription medication exactly as prescribed and contact your doctor if you’re experiencing any issues.

Now you can get genuine, clinically proven ED medication online through Rosemary. Online assessments are 100% confidential and take about 5 minutes to complete. Start your visit with an online doctor for ED treatment today.


Australian Prescriber (May 2019) - Avanafil for erectile dysfunction
Journal of Korean Medical Science (June 2017) - A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Therapeutic Confirmatory Study to Evaluate the Safety and Efficacy of Avanafil in Korean Patients with Erectile Dysfunction
Asian Journal of Andrology (May 2014) - Avanafil for male erectile dysfunction: a systematic review and meta-analysis
Vascular Health and Risk Management (August 2012) - Avanafil for treatment of erectile dysfunction: review of its potential
Therapeutics and Clinical Risk Management (August 2014) - Avanafil for erectile dysfunction in elderly and younger adults: differential pharmacology and clinical utility

ARTG Registered Medications:

Product SPEDRA avanafil 200 mg tablet blister pack is registered in the ARTG, AUST R, Product SPEDRA avanafil 100 mg tablet blister pack is registered in the ARTG, AUST R, Product SPEDRA avanafil 50 mg tablet blister pack is registered in the ARTG, AUST R

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