Prozac (Fluoxetine) for Premature Ejaculation

Finishing too quickly in the bedroom can be embarrassing, but it’s actually one of the most common sexual dysfunctions to affect men. Premature ejaculation, also known as PE, affects up to 31% of Australian men, though the actual number could be much higher due to people not wanting to talk about it with their doctors.

Premature ejaculation is defined as when a man ejaculates always or nearly always within about 1 to 3 minutes of sexual activity. There are different ways to manage PE, from behavioural techniques to prescription medication. One of the prescription premature ejaculation treatments that is prescribed in Australia is Prozac. As a prescription-only medication, it is important to understand how it works in order to safely use it as PE treatment.

What is Prozac?

Prozac is the brand name for the generic drug Fluoxetine. They are both prescribed to treat premature ejaculation in men of all ages. They belong to a class of drugs called selective serotonin reuptake inhibitors (SSRIs). SSRIs are typically prescribed to help treat mood disorders like depression, but as a long-acting SSRI, Prozac and Fluoxetine can be prescribed at a lower dose to help delay ejaculation. When prescribed for PE, Prozac and Fluoxetine are 20 mg tablets that are taken orally daily.

What’s the difference between Prozac and Fluoxetine?

Fluoxetine is the generic version of the brand name premature ejaculation treatment Prozac. It is the active ingredient in Prozac that is responsible for its positive effects in treating PE. From a medical perspective, Fluoxetine and Prozac work in the same way and are effective treatments for PE. The difference between Fluoxetine and Prozac could be in the shape of the tablet as well as cost. Generic medications like Fluoxetine are often cheaper than their brand name counterparts.

How do Prozac and Fluoxetine work for premature ejaculation?

Selective serotonin reuptake inhibitors (SSRIs) work by increasing serotonin levels in the brain. Serotonin plays an important role in ejaculation control systems by inhibiting the reuptake of serotonin (5-HT receptors) and leading to delayed ejaculation. 

Prozac and Fluoxetine are long-acting SSRIs that, when taken daily, can improve PE symptoms. 

Side effects of Prozac

Like all medications, there are potential side effects when taking Fluoxetine or Prozac. The most common mild side effects include:
- Nausea
- Headaches
- Dizziness

More serious side effects can occur. If you experience any of the following, call 000 for assistance.
- Fainting
- Seizures
- Blurred vision

Prozac and Fluoxetine compared to other premature ejaculation treatments

Which premature ejaculation treatments are best? It’s important to note that everyone is different and certain medications will be more effective for some people than others. Fluoxetine and Prozac are long-acting SSRIs and need to be taken daily to maximise efficacy for treating PE. Another long-acting SSRI that can be used for PE is Paroxetine. Both are generally well-tolerated and have been clinically proven to improve premature ejculation symptoms, which is why they are prescribed off-label for PE patients.

A short-acting SSRI that can be taken on-demand instead of daily is Priligy. Priligy is the only premature ejaculation treatment in Australia that is prescribed specifically for PE.  

Is Prozac safe?

Yes, Prozac and its generic counterpart Fluoxetine are both safe to use to treat premature ejaculation. However, it may not be suitable for men with a history of depression or other mental health disorders, low blood pressure or other heart problems, liver problems or kidney problems. Prozac or Fluoxetine should not be taken together with any medications to manage your mood such as antidepressants. It is important to disclose as much accurate medical information as possible to your doctor to assist them in providing the most appropriate treatment options for you.

Depending on your medical history, symptoms and needs, your doctor will prescribe an appropriate premature ejaculation treatment. Like all medications, there are potential side effects to be aware of. Always use your prescription medication exactly as prescribed and contact your doctor if you’re experiencing any issues.

Now you can get genuine, clinically proven PE medication online through Rosemary. Online assessments are 100% confidential and take about 5 minutes to complete. Start your visit with an online doctor for premature ejaculation treatment today.


Medicine Baltimore (February 2019) - Effectiveness and safety of fluoxetine for premature ejaculation
Central European Journal or Urology (June 2019) - Comparison of the treatment efficacies of paroxetine, fluoxetine and dapoxetine in low socioeconomic status patients with lifelong premature ejaculation
International Society for Sexual Medicine (May 2014) - An Update of the International Society of Sexual Medicine's Guidelines for the Diagnosis and Treatment of Premature Ejaculation (PE)
International Brazilian Journal of Urology (December 2019) - Which of available selective serotonin reuptake inhibitors (SSRIs) is more effective in treatment of premature ejaculation? A randomized clinical trial
Australian Family Physician (October 2015) - Premature ejaculation: A clinical review for the general physician

ARTG Registered Medications:

Product ZACTIN TABS fluoxetine hydrochloride 20mg dispersible tablet bottle is registered in the ARTG, AUST R, Product FLUOXETINE DISPERSIBLE TABLETS 20mg (AF) bulk is registered in the ARTG, AUST R, Product FLUOXETINE 20mg TABLETS bulk (AF) is registered in the ARTG, AUST R, Product PROZAC TAB fluoxetine (as hydrochloride) 20mg tablet blister pack is registered in the ARTG, AUST R, Product PROZAC 20 fluoxetine 20mg (as hydrochloride) capsule is registered in the ARTG, AUST R

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